Your argument is based on "could potentially." That says it all,...

Your argument is based on "could potentially." That says it all, really.

No it's not. You just showed me a 388 page thesis - I hadn't read it all - but I'd already referred (see post 6766566 above with figure) to the fact that the CYN.iMSCs 1 2 and 3 did not exactly overlap. That slide is from the poster - but the same thing is on page 248 of the thesis.



Also, I've previously posted a similar observation when this poster was last discussed - from the paper in the thesis -

That figure 1 shows "heterogeneity with individual MSC clones". Its just a cartoon like picture but its in 2D and it shows that cells in the centre of a cluster of cells can get different signals than cells on the edge. CYP cells will be grown on 2D surfaces. That sort of centre versus exterior arrangement can happen on 2D surfaces.

All I'm saying at this point is that the thesis and the paper in the thesis show that some heterogeneity/variability exists even within a set of cells like iMSCs - like different batches - and that that is what the above figure shows.

I'm still reading the thesis - it seems that cells in a set - like the CYP iMSCs may vary in that some of them are at different places in the cell cycle to others so some variation may be occuring in their transcription profiles as a result of that. Too early to be conclusive - but its not too early to observe that there is variation shown there in the paper - and the thesis - itself.

I'm going to look at your DFU paper - but separately.