Ann: Successful Competitive Drug Evaluation in Animals, page-19

This was the standout for me in yesterday's announcement...

"The result from the retinal pigment epithelium/choroid layer of the eye demonstrates no efficacy of the ‘naked’ PS ASO at 0.8 micrograms per eye3 nor the escalated dose of 10 micrograms per eye for the PS backbone ASO whereas the CPP-PMO demonstrates substantial efficacy at the lower 0.8 microgram dose."

If you refer to page 2 of the announcement dated 27/06/19 below, you will note, that not only are PYC are able to go through the 8 different layers of cells, but all the way down to the retinal pigment epithelium/choroid layer and then deliver the ASO cargo across the cell membrane and into this layer of cells - the RPE cells.

https://phylogica.com/wp-content/uploads/2019/06/190627_Break-Through-Animal-Model-Results_1942259.pdf

I wonder if PYC's peers read-outs are measuring the "retinal pigment epithelium/choroid layer", which is the deepest cellular layer of the retina (refer to diagram).

Tony