Ann: Successful Completion of Key Translational Milestone, page-18

grimloq the rabbit eye has different mechanics/cascading properties hence the translational efficacy dosage for effectiveness was 40 for human equivalent at 40x effectiveness

Thank God for today’s announcement; lays a new foundation for the platform/drug proving that it:

1) works - mouse, rabbit, human cells
2) safe - NHP data points to be it being 100% safe below 112…

Aligns previously with reported data - for VP-001 and VP-002 - very exciting times, as both drugs have data to point it being in the safe and effective basket - next 3 months to determine optimal dosage and frequency, eg:

1) twice every year at lower dose
2) once every year at higher dose

All the best fellow holders, further interesting points is that

1) PYC is now up to 5 potential ocular therapeutic leads (with a hint for more in the future), yet only three has been announced (VP-001, VP-002, PYC-001) - the team must be busy

2) Expanding soon beyond rare diseases to tackle common diseases with larger population sets

FYI -previous dosage indications reported were at v.low doses