No problem Rogues.
You might find this news piece interesting.
https://labiotech.eu/medical/replimune-ipo-cancer-immunotherapies/
What's also interesting is that on page 30 of the presentation dated 06/11/17 below, the company highlighted that FPP efficiently targeted cross presenting dendritic cells for an effective peptide vaccine, but what caught my attention was that both CD8 and CD4 T Cells were highlighted under "T Cell Activation and Expansion". The company only highlighted endosomal escaping CPPs would result in CD8+ T cell expansion via MHC I loading and an FPP delivered antigen would lead to greater expansion of CD8+ T cells compared to TAT. I'm still wondering whether there has been any specific work conducted on CD4 T Cells.
http://phylogica.com/wp-content/uploads/2017/11/171106_Matrix-Datapack_BioEurope.pdf
Now take note of the title in today's announcement...
"Successful in vivo results – peptide vaccine T-cell expansion"
Interesting times.
Tony
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