The design would work if the chance of being infected depends more on where you live than on your activities.
e.g. if the mosquitos are locallsed.
Depending on the MOA, you might already be invested in a prophylactic. I'm thinking of CP and MOP of a completely different drug, whose name starts with the letter "b".
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Ann: Successful Phase 2 clinical trial of ISLA-101, page-65
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