Arrowhead Pharmaceuticals has announced a global collaboration and license agreement with Horizon Therapeutics for ARO-XDH, a potential orphan drug treatment for people with uncontrolled gout. ARO-XDH, which targets the primary source of serum uric acid, is a previously undisclosed, discovery-stage RNAi therapeutic.
Under the terms of the agreement, Arrowhead will be responsible for taking ARO-XDH through preclinical development while Horizon will be responsible for the drug’s clinical development and commercialization. Horizon has paid Arrowhead US$40 million upfront for a worldwide exclusive license. Arrowhead is also eligible to receive up to US$660 million in potential development, regulatory and commercial milestones, and is further eligible to receive royalties in the low- to mid-teens range on net product sales.
https://ir.arrowheadpharma.com/news...ceuticals-and-horizon-therapeutics-announce-0
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