▪ RP2D is the dose that does not exceed the DLT limit established by the. dose escalation plan. ▪ Often it is exceeded during the course of a phase 1 study. ▪ The dose escalation scheme is guided by the DLTs that occur during. the observation period, but the safety and tolerability determinations.
Hope this helps…
▪ RP2D is the dose that does not exceed the DLT limit...
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