In regards to Acne - I think this is what went wrong."CBD is...

In regards to Acne - I think this is what went wrong.

"CBD is undergoing Phase 2 clinical trials for the topical treatment of acne (NCT03573518) and atopic dermatitis (NCT03824405), based on its reported anti-inflammatory properties. Given that both skin diseases are also associated with bacterial infections, we were interested to undertake a more detailed examination of CBD’s antimicrobial properties. A key distinction of these current studies is that they are based on synthetic CBD, rather than the purified extracted CBD used in previous reports, avoiding the potential for batch-to-batch variability due to different plant sources, which may lead to distortion of results due to minor but potentially potent biologically-derived impurities. Our studies demonstrate that CBD has consistent activity against a wide range of Gram-positive bacteria, including a variety of drug-resistant strains. Intriguingly, this activity extends to a small subset of Gram-negative bacteria, including pathogens of concern such as Neisseria gonorrhoeae. Preliminary structure-activity relationship studies indicate that there is scope for improving the antibiotic properties of CBD, with further research needed to develop analogs with systemic in vivo activity."