I already knew the cells work best when patients are dosed early. I've been writing that for years. I couldn't see how else they'd work if not responding to signals of inflammation.
It's about not using the cells after multiple anti-inflammatory agents, particularly steroids. I was annoyed this wasn't stipulated in the trial but at the start of trial there was hype over the China study which was quickly published and I think doctors were keen to try our cells. I don't think SI could have foreseen that steroids would arrive on the scene. The Recovery trial was the catalyst for doctors to return to what they knew and multiple anti-inflammatory agents were used.
The interpretation of 'severe disease' worried me throughout the trial and I wrote that here. If I recall right, SI once said re RA our cells would be suitable for patients who had failed multiple biologics. I couldn't see how that could be with IV delivery for long-term chronic conditions because I see such patients as having already reached the stage of significant aberrant scarring, fibrosis. Hopefully Dr Lightner will have success with endoscopic delivery in IBD and I see application for MPCs direct injection to preserve joints.
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