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25.5¢ paradigm biopharmaceuticals limited..

Ann: Trading Halt, page-276

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Duke2

768 Posts.

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19/08/22

08:04

Post #: 63203174
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Originally posted by Anonnymiss: ↑

Did you even read the conclusions of this PHASE 2 study on Sprifermin that your link referred to:

"Conclusions and relevance: Among participants with symptomatic radiographic knee osteoarthritis, the intra-articular administration of 100 μg of sprifermin every 6 or 12 months vs placebo resulted in an improvement in total femorotibial joint cartilage thickness after 2 years that was statistically significant, but of uncertain clinical importance; there was no significant difference for 30 μg of sprifermin every 6 or 12 months vs placebo. Durability of response also was uncertain."

Hardly seem like "competition" based on this study, if you have read any actual detail on the Paradigm PHASE 2 results.

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And then a 2021 meta-analysis of 8 studies showing that the cartilage increases but has no benefit whatsoever.

"The data from the included studies provide strong evidence to determine the effect of intra-articular sprifermin on joint structure in individuals with KOA and show no specific adverse effects. Nevertheless, intra-articular sprifermin did not likely have any positive effect on symptom alleviation."

I'm sure patients will be lining up....

PAR Price at posting: $1.31 Sentiment: Buy Disclosure: Held
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