Hi Jockthegreat,
The average ALSFRS score on MND diagnosis is 38.7 +/- 5.64.
Our longest patient on the MND trial post diagnosis is 48 months.
Relyvrio reduces the ALSFRS by minus 1.24 per month.
The average longevity for a patient on a minus 0.6 score per month is 46.5 months. So that's nigh on 4 years
The autophagy Monepantel affect is cumulative over time.
MT was chatting about it from the 31 minute mark about the proposed ALSFRS scores here.
A one point drop on the ALSFRS score equals an increased mortality of 7%.
The ALSFRS score is not linear. So if Monepantel drops the score to a minus 0.6 units per month it doesn't mean the mortality rate is 4%.
They will be using Bayesian statistics to get a probability distribution of the mortality rate v ALSFRS so I come up with the figure of 6 years
Its the best I can calculate.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950444/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987707/
Kpax
Hi Jockthegreat,The average ALSFRS score on MND diagnosis is...
Add PAA (ASX) to my watchlist
 (20min delay)
|
|||||
|
Last
22.0¢ |
Change
0.000(0.00%) |
Mkt cap ! $86.90M | |||
| Open | High | Low | Value | Volume |
| 22.0¢ | 22.0¢ | 20.0¢ | $191.1K | 906.4K |
Buyers (Bids)
| No. | Vol. | Price($) |
|---|---|---|
| 1 | 1300 | 21.0¢ |
Sellers (Offers)
| Price($) | Vol. | No. |
|---|---|---|
| 22.0¢ | 9563 | 1 |
View Market Depth
| Last trade - 16.10pm 03/05/2024 (20 minute delay) ? |
|
|||||
|
Last
21.0¢ |
Change
0.000 ( 6.67 %) |
||||
| Open | High | Low | Volume | ||
| 22.0¢ | 22.5¢ | 20.5¢ | 533029 | ||
| Last updated 15.54pm 03/05/2024 ? | |||||
| PAA (ASX) Chart |