Why was Vioform "a brilliant drug" as Skint told and why was it used also by others working in similar places and exposed to developing chronic diarrhea or other infections by antibiotic-resistant bacteria? Why now when oral Vioform is not available a similar new safe drug also for oral usage is needed?

The gut is the place to develop new antibiotic-resistant bacteria but PBT2 prevents this as did Vioform in the '70s ( see the PBT2 publications by QU microbiologists). Vioform was used as preventive medicine and not only when you got traveler's diarrhea caused by bacteria. Vioform worked in both ways and so will also PBT2, no doubt, IMO.

Below there is an article demonstrating what happens to the "Skints" even today when traveling to Africa and when we do not have Vioform anymore. I sent this paper to ATH a few years ago as a possible model demonstrating perhaps the effect of PBT2 but for sure the otitis media is a better plan. I have posted this also on this board earlier.

Now when we have neither Vioform nor PBT2 these travelers come home and spread the infection by various means and so there will be antibiotic-resistant bacteria in their surroundings. There will be antibiotic-resistant gonorrhea, otitis, pneumonia, urinary infections, etc, even killing people.

BMC Infect Dis

. 2018 Jul 23;18(1):341.

doi: 10.1186/s12879-018-3245-z.

Extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) among travellers to Africa: destination-specific data pooled from three European prospective studies

Tinja Lääveri ¹, Jessica A Vlot ², Alje P van Dam ^{3 4}, Hanni K Häkkinen ⁵, Gerard J B Sonder ^{3 4}, Leo G Visser ², Anu Kantele ^{6 7 8 9}

Affiliations expand

• PMID: 30037325

PMCID: PMC6057027 DOI: 10.1186/s12879-018-3245-zFree PMC article

Abstract

Background: One third of travellers to low- and middle-income regions of the tropics and subtropics become colonized by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE). The risk varies by destination and, for each traveller, may be substantially further increased by travellers' diarrhoea (TD) and antibiotic use. Despite the risk of TD in Africa, ESBL-PE acquisition rates in all studies are lower there than in Asia. Africa has become increasingly popular as a destination for international travellers, yet minimal data are available from the continent's subregions and countries.

Methods: We analysed subregion- and country-specific data on carriage and risk factors for ESBL-PE colonization pooled from three prospective studies conducted between 2009 and 2013 among Finnish and Dutch travellers. The data were subjected to multivariable analysis of risk factors. In addition, we compared our data to two recent large investigations reporting data by subregion and country.

Results: Our joint analysis comprised data on 396 travellers. The ESBL-PE colonization rate was highest in Northern Africa, followed by Middle and Eastern Africa, and lowest in Southern and Western Africa. Of individual countries with more than 15 visitors, the highest rates were seen for Egypt (12/17; 70.6%), Ghana (6/23; 26.1%), and Tanzania (14/81; 17.3%); the rates among travellers to Egypt were comparable to those reported in South and Southeast Asia. In a pooled multivariable analysis, travel destination, age, overnight hospitalisation abroad, TD, and use of fluoroquinolones were independently associated with increased ESBL-PE colonization rates.

Conlusions: Even in areas with relatively low risk of colonization, antimicrobials clearly predispose to colonization with ESBL-PE. Travellers to Africa should be cautioned against unnecessary use of antibiotics.



IMO, PBT2 will get external funds for the research needed because it is so important when an effective means to control antibiotic-resistant infections is needed. Every penicillin, ampicillin, tetracycline, etc manufacturer needs PBT2 in preventing colonization caused by these drugs. These antibiotics are part of the cause of antibiotic-resistant infections as is clearly presented in the paper above. Only by a combination with PBT2, you can use these antibiotics so that you do not create a worse problem, an antibiotic-resistant infection.

PBT2 is a must for the antibiotic manufacturers, they need to fund it. Without it, they will get in trouble paying millions for causing antibiotic-resistant infections.