Phylogica are targeting various pathways.
Here's one example: TLR signalling pathways i.e., inhibiting targets that play a crucial role in inflammation.
"The target TLR adaptor is amenable to number of chronic and acute inflammatory diseases"
See here: (Slide 16 to 29)
http://www.phylogica.com/webbox/media/PaulWattPeptalk08%20-%20lowres.pdf
And let's not forget that blood brain delivery for targeting neurodegeneration is a very very hot area at present.
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