Interesting!
So in short, T-cell therapies are being used to turn ‘cold’ tumours ‘hot’ where CPI do not.
Good thing there is strong correlation between CD8+ levels and FTO expression. Thus Inhibiting FTO might yield similar benefits albeit via a different pathway.
At the end of the day, if the tap can be turned from cold to hot, doesn’t matter how it was done!
Ann: Zantrene Improves Immune Therapy Treatment of Melanoma, page-84
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