MethOxyfluraNe in InTerventiOnal Radiology (MONITOR): A randomised controlled trial
Ross Copping et al. J Med Imaging Radiat Oncol.2024.
https://pubmed.ncbi.nlm.nih.gov/38923825/
Results: One hundred and sixty-nine patients received methoxyflurane and 145 received placebo. Baseline characteristics were similar between the two groups. The methoxyflurane group had lower pain and anxiety scores throughout the procedure (P < 0.001) with 2.5 times less pain (VAS 1.08/10) and 1.6 times less anxiety (VAS 0.97/10) on average. Lower post-procedure pain (mean 0.72 vs 1.44; P < 0.001) and anxiety (mean 0.55 vs 1.13; P = 0.008) were also observed with methoxyflurane. There were no drug or major procedure-related adverse events.
Conclusion: The results of this study suggest that methoxyflurane provides safe and effective analgesia and anxiolysis for some procedures in IR.
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