you and the rest of the bullshit peanut brigade - if you have a need for it and when it's successful - will fall over yourselves to get a working vaccine
the last thing you'll want to do is to wait ------- the epitome of hypocrisy
The latest and most significant development in vaccines for skin cancer is the ongoing phase 3 clinical trial of the world's first personalized mRNA cancer vaccine for melanoma, the deadliest form of skin cancer. [1][2][3][4][5]
## Key Points
- The vaccine, called mRNA-4157 (V940), is a personalized neoantigen therapy designed to stimulate the immune system to combat a patient's specific type of melanoma tumor.
- It is being developed by Moderna and Merck, and works by carrying coding for up to 34 neoantigens (tumor-specific markers) to trigger an anti-tumor immune response based on the unique mutations in a patient's cancer.
- The vaccine is custom-built for each patient by sequencing their tumor DNA and using AI to identify the neoantigens, making it a truly personalized treatment. [1]
- In a phase 2 trial, patients who received the mRNA vaccine along with the immunotherapy drug Keytruda were 49% less likely to die or have their cancer return after 3 years compared to those who received only Keytruda. [1][3]
- Based on these promising results, a global phase 3 trial involving around 1,100 melanoma patients has now commenced, with the UK arm aiming to recruit 60-70 patients across 8 centers. [1][2]
- One of the first UK patients, Steve Young, expressed excitement about the trial, calling it his "best chance at stopping the cancer in its tracks." [1][2]
- If successful, the personalized mRNA vaccine could be a game-changer in melanoma treatment, potentially leading to a cure for some patients. Experts have hailed it as a "finely honed tool" and "one of the most exciting things seen in a long time." [1][2][4][5]
The personalized mRNA vaccine represents a revolutionary new approach in cancer treatment, harnessing the body's own immune system to fight the disease in a highly targeted and customized manner. [5] The ongoing phase 3 trial results will determine if this cutting-edge therapy can be approved for broader use against melanoma and potentially other cancers in the future.
