I am just making an educated guess as to what the toxicity is. You seem to love the elephant analogy, but it is more like the mongoose looking for the snake.
We have been told they are currently speaking to european regulators. An easy resolution to the problem is dependent on those talks. That is what I know.
I also know a MPAC[CQ] when used in a study of Multiple Sclerosis it reduced spinal cord demyelination.
[The CQ-mediated inhibition of the clinical course of EAE was accompanied by suppression of demyelination and reduced infiltration by encephalitogenic immune cells including CD4, CD8, CD20 and F4/80 positive cells. CQ also remarkably inhibited EAE-associated BBB disruption and MMP-9 activation. Autophagy contributes to clearance of aggregated proteins in astrocytes and neurons. The present study found that EAE increased the induction of autophagy and CQ further increased this expression. Furthermore, the present study found that post-treatment with CQ also reduced the clinical score of EAE and spinal cord demyelination. ]
https://www.ncbi.nlm.nih.gov/pubmed/23360710
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- Approved drugs with CNS demyelination side effect.
I am just making an educated guess as to what the toxicity is....
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