ARC linkage grant, page-11

This is interesting and gives context to "Cyclops" ??? asked the question when the presentation was put up earlier this year in the US but is the tiered structure of image just arty farty or does it imply that it's the next to see a commercial transaction ? Also worth noting that Peptidream is all partnered out based on non-standard macrocylic peptides ---- still cracking along from their share split back to $2B market cap - aud.


Phylogica set to expand peptide libraries

Jul 14 2015 - 5:12 pm
In the sequel to a $670k ARC linkage grant, Phylogica seems set to further expand its world-leading peptide libraries.

Key recipient of the grant is Prof Kirill Alexandrov at the Institute for Molecular Bioscience University of Queensland.

In partnership with $PYC Alexandrov aims to develop a novel strategy for the production of polypeptides with unnatural chemical groups using a sense codon reassignment approach.


http://www.do not advertise external blogs.com.au/wp-content/uploads/2015/07/0c3a382-150x150.jpg
Prof Kirill Alexandrov, Institute for Molecular Science, UQ


Peptides made of 20 natural amino acids cover only a very small fraction of the available chemical and functional space, Alexandrov says.

While a peptide’s functionality can be extended with unnatural amino acids, the methods for their site-selective incorporation are inefficient.

The project’s strategy relies on the depletion of selected tRNAs from an in vitro protein translation system and their replacement with synthetic tRNAs, charged with unnatural amino acids.

It is expected that the developed technology could be used to rapidly generate and screen highly diversified macrocyclic peptide libraries."

http://www.do not advertise external blogs.com.au/phylogica-set-to-expand-peptide-libraries/