Dermatological
New Onset and Exacerbations of Psoriasis Following COVID-19 Vaccines: A Systematic Review
https://link.springer.com/article/10.1007/s40257-022-00721-z
(A systematic literature search of 43 studies showed mRNA vaccines, produced by Moderna and BioNTech/Pfizer, were frequently associated with psoriasis episodes. First, second, and third vaccine doses were associated with psoriasis incidents, with the second dose most frequently associated with psoriasis flares.)Management of oral lesions following COVID-19 vaccination
https://onlinelibrary.wiley.com/doi/10.1111/odi.14342
(“Most common oral lesions reported in the literature following COVID-19 vaccination include maculae, petechiae, desquamation, edema, erythema multiforme-like lesions, erosions, and ulcers on the hard palate, oral floor, lips, tongue, and gingiva” Explanatory article here.)Occurrence of erythema multiforme following COVID-19 vaccination: a review
https://ecevr.org/DOIx.php?id=10.7774/cevr.2023.12.2.87
(EM is an acute self-limiting reaction caused by exaggerated immune response, which is characterized by targetoid skin lesions that may be associated with mucosal involvement as well. Review of patients with EM as a side effect of COVID-19 vaccination across several studies. “EM is among the oral mucocutaneous side effects of COVID-19 vaccines.” Explanatory article here.)Incidence of Chronic Spontaneous Urticaria Following Receipt of the COVID-19 Vaccine Booster in Switzerland
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800873
(Swiss doctors report a strong link between the Moderna booster and chronic hives. Adults who got Moderna developed hives 15 times as often as those who got Pfizer.)A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendations about vaccination of important immune-mediated dermatologic disorders
https://onlinelibrary.wiley.com/doi/10.1111/dth.15461
(Paper summarizes a stunning 180 papers/reports from the first seven months of the vaccination campaign alone, describing in exhaustive tables the wide range of skin rashes and disorders of the mucosal surfaces (mouth/nose/anus) where the Spike protein from the vaccine and or inflammatory mediators cause dermatological manifestations. There has never been a vaccine that has this degree of well-documented, serious dermatological toxicity. Explanatory article here.)Cutaneous vasculitis: Lessons from COVID-19 and COVID-19 vaccination
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1013846/full
(A mini-review stated that cases of vasculitis of the skin “have been more frequently reported” after COVID-19 vaccinations than after infection.)Diabetes
Metformin mitigates insulin signaling variations induced by COVID-19 vaccine boosters in type 2 diabetes
https://www.medrxiv.org/content/10.1101/2023.12.27.23299358v1
(Authors report that “61.1% of patients with type 2 diabetes, but not healthy controls, exhibited aggravated insulin resistance towards the booster shots of the COVID-19 vaccine.” Also, about 66.7% of diabetic subjects had increased risks of cardiovascular complications. The authors, after conducting a very deep investigation, proved that Covid vaccines impair glucose tolerance in diabetics via spike protein that they encode. Explanatory article here.)Hyperglycemic Emergencies Associated With COVID-19 Vaccination: A Case Series and Discussion
https://academic.oup.com/jes/article/5/11/bvab141/6375389
(explanatory article: Reports on three cases of people who developed severe dysregulation of their blood sugar just days after mRNA vaccinations. “The temporal onset of symptoms… and the brisk clinical course strongly suggests that the hyperglycemic emergencies were trigged by the COVID-19 vaccination,” the authors wrote.)Eye Disorders
Characteristics and Clinical Ocular Manifestations in Patients with Acute Corneal Graft Rejection after Receiving the COVID-19 Vaccine: A Systematic Reviewhttps://www.mdpi.com/2077-0383/11/15/4500
(Cornea grafts are considered a much lower-risk transplant procedure than solid organ transplants with a much lower rejection rate. Thus, researchers were surprised to find a total of 23 eyes from 21 patients who had undergone corneal graft procedures who experienced rejection anywhere from one day to six weeks following COVID vaccination. In some cases, the rejection occurred suddenly after being jabbed despite the cornea graft having held steady for many years. Explanatory article here.)Risk assessment of retinal vascular occlusion after COVID-19 vaccination
https://www.nature.com/articles/s41541-023-00661-7
(Following vaccination, there is a prolonged increased risk of retinal vascular occlusion in all ages. Over two years, the risk of RVO is doubled. Explanatory articles here and here.)COVID-19 Vaccine-Associated Optic Neuropathy: A Systematic Review of 45 Patients
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609672/pdf/vaccines-10-01758.pdf
(Description of an injury pattern in which lipid nanoparticles settle along the artery or into the central nerve taking visual signals to the brain, then inflammation fighting the foreign Spike protein that starts a process of tissue damage leading to loss of vision.)The Eye of the Storm: COVID-19 Vaccination and the Eye
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8675299/
(A literature review consisting mainly of case reports and case series, representing possible ocular side effects associated with COVID-19 vaccines.)Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospectivehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875181/
(“Since the introduction of COVID-19 vaccinations, numerous reports have commented on adverse ocular events following vaccination. In this review, we sought to present these in a systematic fashion and offer insights into the mechanisms and clinical considerations surrounding these phenomena.”)UVEITIS AFTER THE BNT162b2 mRNA VACCINATION AGAINST SARS-CoV-2 INFECTION: A Possible Associationhttps://pubmed.ncbi.nlm.nih.gov/34369440/
(Uveitis may develop after the administration of the BNT162b2 mRNA vaccine. The most common complication was mild to moderate anterior uveitis.)Retinal Toxicity of Polyethylene Glycol (PEG)-400https://iovs.arvojournals.org/article.aspx?articleid=2359098
(Study concludes that the intravitreal injection of polyethylene glycol-400 is toxic to retina and it should not be used as a vehicle in the eye.)Increased Susceptibility to C19 Infection
Risk of SARS-CoV-2 infection and hospitalization in individuals with natural, vaccine-induced and hybrid immunity: a retrospective population-based cohort study from Estonia
https://www.nature.com/articles/s41598-023-47043-6
(“Individuals with vaccine-induced immunity were at higher risk than those with natural immunity for infection and hospitalization. Vaccination made risks worse particular during the Delta wave.” Explanatory article here.)IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein
https://www.mdpi.com/2076-393X/11/5/991
(“… emerging evidence suggests that the reported increase in IgG4 levels detected after repeated vaccination with the mRNA vaccines may not be a protective mechanism; rather, it constitutes an immune tolerance mechanism to the spike protein that could promote unopposed SARS-CoV2 infection and replication by suppressing natural antiviral responses… repeated mRNA vaccination may also cause autoimmune diseases, and promote cancer growth and autoimmune myocarditis in susceptible individuals.” Explanatory article here.)Forgotten “Primum Non Nocere” and Increased Mortality after COVID-19 Vaccination
https://www.primescholars.com/articles/forgotten-primum-non-nocere-and-increased-mortality-after--covid19-vaccination.pdf
(“Calculations confirm that the mortality of the vaccinated coronavirus infected groups was 14.5% higher on average than the mortality of non-vaccinated coronavirus infected groups. Conclusion: Vaccinated infected groups appear to have higher average mortality than their non-vaccinated infected counterparts.”)Effectiveness of the Coronavirus Disease 2019 Bivalent Vaccine
https://academic.oup.com/ofid/article/10/6/ofad209/7131292?login=false
(Known as the Cleveland Clinic study, it shows that the chances of contracting COVID-19 increase with each additional dose of COVID-19 vaccine. See figure 2 of the study. Basically, the more jabs, the more and faster the covid infections. Over a 90 day period participants with 3 or more doses faced a risk of catching COVID up to 6x than the baseline. Every dose proportionately increased the risk of infection, strongly suggesting correlation.)Antinucleocapsid Antibodies After SARS-CoV-2 Infection in the Blinded Phase of the Randomized, Placebo-Controlled mRNA-1273 COVID-19 Vaccine Efficacy Clinical Trial
https://www.acpjournals.org/doi/10.7326/M22-1300
(This paper points out that the more times people are vaccinated, the less likely they are to develop broad-based immunity when they get the actual virus. What this means is the more vaccines you get, the less likely you are to develop full immunity from the virus.)Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5
https://www.nature.com/articles/s41467-023-35815-7
(A Kaiser Permanganate study that shows negative efficacy of the shots against all variants within 150 days. And this study shows the more you inject, the more you infect; specifically, over time, those with three doses fare worse than those with two.)Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
https://www.science.org/doi/10.1126/sciimmunol.ade2798
(Study suggests that vaccinated people may be developing a systemic tolerance for toxic spike protein. To put it simply, this antibody class shift is bizarre, unprecedented, and a very troubling sign that vaccinated people—especially repeatedly dosed people—are somehow losing their IgG1 and especially IgG3 response in favor of IgG4. Meaning it’s a reduction of the two effective neutralizing antibody types, and increase in the least effective type IgG4, which is actually for allergies and doesn’t remove the foreign proteins so much as teach the body to “tolerate” or “ignore” them. Specifically, whereas IgG1 and IgG3 types are “pro-inflammatory,” which means they trigger the body’s immune-system high alert system, the IgG4 type is “anti-inflammatory,” which means it tells the immune system to stand down. Which is the opposite of what you really want, when you’re fighting an infection.)Conserved longitudinal alterations of anti-S-protein IgG subclasses in disease progression in initial ancestral Wuhan and vaccine breakthrough Delta infections
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1043049/full
(Just like the above study, researchers found higher ratios of IgG4 were associated with more severe disease, and people who had high levels of IgG4 antibodies relative to IgG3 had worse clinical outcomes, meaning they got sicker.)Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection
https://www.nejm.org/doi/full/10.1056/NEJMc2202092
(Study shows that boosted subjects cleared the virus more slowly than unvaccinated people, and that the share of boosted subjects who were still contagious (31%) at day ten was over five times more than the share of still-contagious unvaccinated subject (6%).)Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
https://www.science.org/doi/10.1126/science.abq1841
(“This “hybrid immune damping” indicates substantial subversion of immune recognition and differential modulation through immune imprinting and may be the reason why the B.1.1.529 (Omicron) wave has been characterized by breakthrough infection and frequent reinfection with relatively preserved protection against severe disease in triple-vaccinated individuals.”)Increases in COVID-19 are unrelated to levels of vaccination across 68 countries and 2947 counties in the United States
https://link.springer.com/article/10.1007/s10654-021-00808-7
(In fact, the trend line suggests a marginally positive association such that countries with higher percentage of population fully vaccinated have higher COVID-19 cases per 1 million people.)Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease
https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13795
(Vaccines designed empirically using the traditional approach, be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID‐19 disease via antibody‐dependent enhancement (ADE). This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID‐19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials.)Effects of Vaccination and Previous Infection on Omicron Infections in Children
https://www.nejm.org/doi/full/10.1056/NEJMc2209371
(Study shows that children who had Covid and were subsequently vaccinated, were much more likely to get reinfected than their peers who also had Covid, and were NOT vaccinated. In other words, for kids who had Covid, getting them vaccinated made them much more susceptible to reinfections. Explanatory article here)(SARS-CoV-2) Naturally Acquired Immunity versus Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: A Retrospective Cohort Study
https://academic.oup.com/cid/article/75/1/e545/6563799
(As demonstrated in this paper, people whose immune response was induced by Pfizer’s mRNA product—versus natural immunity—were at 13-times greater risk of being infected with SARS-CoV-2. Explanatory article here.)Severity of SARS-CoV-2 Reinfections as Compared with Primary Infections
https://www.nejm.org/doi/10.1056/NEJMc2108120
(explanatory article: “These data show show that the vaccinated are 10.29 mores likely to suffer from severe or critical COVID-19 or death upon reinfection than those with natural immunity.”)Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
https://pubmed.ncbi.nlm.nih.gov/35862508/
(Study shows increased risk of infection in the vaccinated. Explanatory article)Inflammation
Correlation between COVID-19 vaccination and inflammatory musculoskeletal disorders
https://www.medrxiv.org/content/10.1101/2023.11.14.23298544v1.full-text
(The researchers searched the medical records of 2.2 million patients looking for correlations between jabs and inflammatory diseases of the muscles or skeletal system "Individuals who received any COVID-19 vaccine were more likely to be diagnosed with inflammatory musculoskeletal disorders than those who did not. All COVID-19 vaccines were identified as significant risk factors for each inflammatory musculoskeletal disorder.")New-Onset Rheumatic Immune-Mediated Inflammatory Diseases Following SARS-CoV-2 Vaccinations until May 2023: A Systematic Review
https://www.mdpi.com/2076-393X/11/10/1571
(Review suggests that COVID vaccines “may trigger” rheumatic immune-mediated inflammatory diseases, including arthritis, vasculitis, lupus, and adult-onset Still’s disease. "This SR highlights that SARS-CoV-2 vaccines may trigger R-IMID" Also, "The short time span between COVID-19 vaccine administration and the onset of R-IMIDs suggests the potential possibility of a cause-and-effect relationship" Explanatory article here.)Abstract 10712: Observational Findings of PULS Cardiac Test Findings for Inflammatory Markers in Patients Receiving mRNA Vaccines
https://www.ahajournals.org/doi/abs/10.1161/circ.144.suppl_1.10712
(Heart surgeon Dr. Steven Gundry performed a test that utilizes inflammatory markers to predict the risk of an acute coronary syndrome (e.g., a heart attack) in the next five years on 566 patients and found that before vaccination their risk averaged 11%, while afterward, it averaged 25%.)Reported cases of multisystem inflammatory syndrome in children aged 12–20 years in the USA who received a COVID-19 vaccine, December, 2020, through August, 2021: a surveillance investigation
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(22)00028-1/fulltext
(The authors concluded that, “Continued surveillance for MIS-C illness after covid-19 vaccination is warranted” and encouraged doctors to “report potential MIS-C cases after covid-19 vaccination to VAERS.” Explanatory article here.)SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitishttps://www.sciencedirect.com/science/article/pii/S0168827822002343
(“COVID19 vaccination can elicit a distinct T cell-dominant immune-mediated hepatitis with a unique pathomechanism associated with vaccination induced antigen-specific tissue-resident immunity requiring systemic immunosuppression.”)Cutaneous vasculitis: Lessons from COVID-19 and COVID-19 vaccination
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.1013846/full
(A mini-review stated that cases of vasculitis of the skin “have been more frequently reported” after COVID-19 vaccinations than after infection.)Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases
https://www.jaad.org/article/S0190-9622(21)00658-7/fulltext
(A large study identified several common adverse reactions: rashes, itchy, red skin, and hives.)Kidney / Renal issues
Renal Complications Following COVID-19 Vaccination: A Narrative Literature Review
https://journals.lww.com/ijcm/fulltext/2023/48020/renal_complications_following_covid_19.3.aspx
(This review describes 28 published mechanisms of kidney injury and renal damage from COVID-19 vaccination. Most of the pathways involve inflammation from either direct cytokine damage or auto-immunity. Explanatory article here.)Daily Clout Report 62: Acute Kidney Injury and Acute Renal Failure Following Pfizer mRNA COVID Vaccination.
https://dailyclout.io/report-62-acute-kidney-injury-and-acute-renal-failure-following-pfizer-mrna-covid-vaccination-33-of-patients-died-pfizer-concludes-no-new-safety-issue/
(Pfizer Documents Analysis Project Post-Marketing Group produced an alarming review of the Renal (Kidney) System Organ Class adverse events found in Pfizer documents: 69 patients, including one infant, suffered acute kidney injury or acute renal failure. Half of the severe renal adverse events were reported within four days of vaccination. Pfizer’s renal adverse event reports screen only for the most severe damage but miss important, less severe kidney damage. Thus, Pfizer’s post-marketing kidney adverse events are likely significantly underreported.)Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.765447/full
(Explanatory article here.)Successful treatment of new-onset diabetes mellitus and IgA nephropathy after COVID-19 vaccination: a case report
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10703642/
(“COVID-19 vaccination-related glomerular (kidney) diseases have become a new concern. Both the mRNA vaccine and the inactivated vaccine can cause new-onset and relapsing glomerular (kidney) disease. These diseases typically occur after the first or second dose of vaccination.”)Minimal Change Disease After First Dose of Pfizer-BioNTech COVID-19 Vaccine: A Case Report and Review of Minimal Change Disease Related to COVID-19 Vaccine
https://journals.sagepub.com/doi/full/10.1177/20543581211058271
("...there has been a steady increase in the number of patients presenting with nephrotic syndrome and acute kidney injury after the administration of COVID-19 vaccine. Physicians should be made aware of minimal change disease as a potential complication associated with COVID-19 vaccine.")
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