NB: The last bullet under conclusions on the MITCI poster are...

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tommo88

37 Posts.

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06/06/17

04:30

Post #: 25113105
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Originally posted by coeusthinks ↑

The ASCO 2017 scientific posters are out for Viralytics - https://www.viralytics.com/our-pipeline/scientific-presentations/scientific-presentations-2017/

Haven't had time to digest it all and compare with previous literature. In MITCI, it looks like the key result is the BORR (CR+PR) for Prior anti-PD1 therapy (n=13) reporting 23.1%. I've also noticed that they've omitted any reference to the overall response rate for the intention-to-treat (ITT) population (which was 50%). Not sure how to interpret that. All the other aspects seem fine: DCR - check. Safety profile - check.

Does anyone know if this is a novel result? Is this something that hasn't been previously researched? (I guess in the context of Amgen's ASCO result on T-Vec - it does to some extent)

In KEYNOTE-200, seems like it's another poster providing methodological details similar to previous posters. Overall, nothing really jumps out at me as game changing. Am I missing anything?

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NB: The last bullet under conclusions on the MITCI poster are excellent!! Specifically UNMET NEED. This is the path to fast track approval.

• While preliminary, the data suggest that a CVA21-ipilimumab combination may represent a viable treatment option for an unmet need in advanced melanoma patients refractory to prior anti-PD1+/- CTLA-4 therapies.

VLA Price at posting: $1.05 Sentiment: Buy Disclosure: Held
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NB: The last bullet under conclusions on the MITCI poster are...

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