AVE (ASX) AVE pipeline timeline

Originally posted by hottod: ↑

Research is now showing that CBD can reduce TNF-alpha and interleukin-6 (pro-inflammatory cytokines), which would have potential benefits for certain cardiovascular/inflammatory conditions. We have shown that TPM reduces the same inflammatory cytokines. So, we could potentially increase the absorption of CBD for greater therapeutic effect, while the excipient itself adds some addition value. This is not something associated with standard excipients.

The fact that both CBD and TPM have been demonstrated to reduce levels of the pro-inflammatory cytokines, TNF-α and IL-6, provides an interesting angle to AVE’s TPM/CBD formulation.

As indicated by Paul Gavin, high levels of TNF-α and IL-6 are associated with various cardiovascular and inflammatory conditions.

The scientific literature confirms this, as shown in these excerpts below.

The increased expression of interleukin-6 is closely related to atherosclerosis, myocardial infarction, heart failure and ischemic stroke. It is a key risk factor for these diseases by triggering inflammatory reaction and inducing other molecules release. Therefore, interleukin-6 may become a potential target for Cardio-Cerebrovascular Diseases in the future.

https://www.frontiersin.org/articles/10.3389/fphar.2021.745061/full

The pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-6 have been extensively implicated in the pathogenesis of heart failure.

https://link.springer.com/article/10.1007/s10557-020-07071-0

The interactions between TNF-α and IL-6 exacerbate oxidative stress and reduce phosphorylation of eNOS, thereby contributing to coronary endothelial dysfunction in T2D mice.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187189

Studies have shown an increase in cytokines in idiopathic and heritable PAH (pulmonary arterial hypertension), and higher IL-6 levels are associated with an increased risk of death in PAH.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418312/

There is augmentation of TNF-α and IL-6 levels in diabetic patients and augmentation is more in obese than in nonobese diabetics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334258/

Acute hyperglycemia increases circulating cytokine concentrations, which have been implicated in insulin resistance (TNF-α, IL-6), plaque destabilization (IL-18), and future cardiovascular events (IL-6)

https://www.ahajournals.org/doi/10.1161/01.cir.0000034509.14906.ae

IL-6 and TNF-α, as 2 inflammatory cytokines, might play a vital role in the pathogenesis of RA (rheumatoid arthritis) through their pro-inflammatory effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694713/

…both TNF-α and IL-6 are important pathogenic factors related to immune-mediated bone diseases including rheumatoid arthritis and postmenopausal osteoporosis.

https://www.ingentaconnect.com/content/ben/cdt/2020/00000021/00000003/art00002

Our study showed significant correlation of TNF- α and IL-6 with non-alcoholic fatty liver disease.

http://medical.advancedresearchpublications.com/index.php/MedicineJournal/article/view/160

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality despiteaggressive treatment of traditional risk factors. Chronic inflammation plays an important role in the initiation and progression of CVDs. Inflammatory bowel disease (IBD) is a systemic state of inflammation exhibiting increased levels of pro-inflammatory cytokines including tumour necrosis factor-α (TNF-α, interleukin (IL)-1β, and IL-6. Importantly, IBD is associated with increased risk for CVDs especially in women and young adults, including coronary artery disease, stroke, thromboembolic diseases, and arrhythmias.

https://academic.oup.com/ehjopen/article/2/1/oeab029/6396873?login=false

…our cytokine profiling revealed a significant association of a well-known triad of cytokines—IL-1β, IL-6, and TNF—with PASC (long COVID). Due to their functional role in pain perception, anxiety, depression, and inflammatory symptoms 64, 65, 66, 67, 68, 69, 70, 71, 72, 73 they are well compatible with the spectrum of symptoms in PASC.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214726/

Inflammatory cytokines such as IL-6 and tumor necrosis factor (TNF)-a can produce malaise, fatigue, muscle aches, and loss of appetite (10). Inflammation has been linked to fatigue (11), sleep disturbance, pain (12–15), depression (16, 17), and anxiety (18–20)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418312/

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All very interesting HT but antiinflamatory infection fighters ibuprofen , tipranavir & amprenavir have all been approved with the use of tpgs in the UK & US
Like I said Gavin's claims are debatable .

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All very interesting HT but antiinflamatory infection fighters...

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