"Furthermore, by the 27th of February, the results of 42 clinical trials, including approximately 15,000 patients (both registered and unregistered studies) have been subjected to a meta-analysis after exclusion of biasing factors. It was found that 83% showed improvements with early treatment, 51% improved during late-stage treatment, and there was an 89% prevention of onset rate noted. This confirms the usefulness of ivermectin. Since it is a meta-analysis based on 42 test results, it is estimated that the probability of this comprehensive judgment being a mistake is as low as 1 in 4 trillion. In addition, two separate meta-analyses also showed the 46 （ 46 ） THE JAPANESE JOURNAL OF ANTIBIOTICS 74―1 Mar. 2021 usefulness of ivermectin and their conclusions were presented to the WHO and the US FDA with a request for an expansion of the indication of ivermectin in the treatment of COVID-19" .....
A very good and long read to the background on IVM. Some discussion on in vitro experiment which killed most of the cv19 with 48 hrs, is suggested by nay sayers that same concentration, if to in human blood concentrations would be too high a dose, but is countered by the fact that much smaller doses are demonstrated in the trials above, to actually work well. Hence i would infer, that the levels in vitro, were too high to begin with / or that other modes of action are working in tandem with a lower dosage rate in trials. In essence, a large dose in vitro wiped out cv19 in 48 hrs, and a lower dose is proving quite effective in trials. Either way, IVM is kicking ass.
