My T cells activation levels are on high alert on bla bla bla....

First 10235 Last

Share
Profile

Follow
vasilios

3,800 Posts.

359

18/07/24

09:04

Post #: 74805396
Share

Originally posted by JB1975: ↑

The baseline level is a different number for each patient - it is a number but it could be 10,000 activated T cells per some small unit volume or blood weight of cell count for patient A and 9,000 activated T cells per whatever for patient B and so on.

So a 50% reduction after 28 days for patient A is a T cell count that is half what it was previously for patient A and the same for patient B.

Zero reduction and 100 percent reduction is the range you can't have a more than total reduction of the activated T cells which would be 100% reduction and you can't have less than no reduction.

I think you are interested in can the activated T cells actually go up such that rather than a reduction there would actually be an increase after 28 days? Well in healthy patients that didn't have a lot of activated T cells sure if they happened to be fighting an infection 28 days later that they didnt have before their T cells would be up - but that isn't the starting position here - because if the patients didn't already have relatively high T cell activation levels that would mean the T cells from the graft in their blood weren't actually attacking the host and so you wouldn't have GVHD in the first place.

When you are measuring T cell activation you are specifically measuring T cell based immunity specifically not inflammation. While inflammation and immunity can occur together they aren't the same. Other types of cells would be involved in inflammation.

The T cells are activated (in GVHD its believed) because they think they've encountered a foreign protein (a piece of the host cells that is only about 7 to 9 amino acids long - but those little pieces would be specific enough that the T cells from the graft responding to the foreign to them proteins that were proteins natural to the host but would not have been foreign to the graft that the T cells has come from.

This is not a perfect explanation but I believe its pretty accurate.

Expand

My T cells activation levels are on high alert on bla bla bla. (Bla Bla is biomarker)

MSB Price at posting: $1.13 Sentiment: Buy Disclosure: Held
4 Upvote

0 Great analysis

Reply

Top Stories

AI stocks: What to expect in 2024-25

NRX

Noronex joins forces with South32 to look for copper in Namibia

FMG

Andrew Forrest was seemingly possessed by the spirit of hydrogen – now he's cut 700 jobs and canned FFI

EVN

Evolution shares up 3% on quarterly results for June showing rise in gold production

DMP

Domino's locks in biggest faller status on Thursday as it closes stores in Asia, Europe

There are more pages in this discussion • 26 more messages in this thread...

First 10235 Last

Add MSB (ASX) to my watchlist

(20min delay)
Last $1.10		Change -0.030(2.67%)		Mkt cap ! $1.247B

Open	High	Low	Value	Volume
$1.12	$1.13	$1.09	$3.665M	3.334M

Buyers (Bids)

No.	Vol.	Price($)
18	28978	$1.10

Sellers (Offers)

Price($)	Vol.	No.
$1.10	173115	20

View Market Depth

No.	Vol.	Price($)
24	37283	1.095
19	107422	1.090
23	235810	1.085
27	365722	1.080
16	253694	1.075

Price($)	Vol.	No.
1.100	168870	21
1.105	92904	12
1.110	292575	12
1.115	82691	6
1.120	12892	3

Last trade - 15.00pm 18/07/2024 (20 minute delay)

MSB (ASX) Chart

My T cells activation levels are on high alert on bla bla bla....

AI stocks: What to expect in 2024-25

Noronex joins forces with South32 to look for copper in Namibia

Andrew Forrest was seemingly possessed by the spirit of hydrogen – now he's cut 700 jobs and canned FFI

Evolution shares up 3% on quarterly results for June showing rise in gold production

Domino's locks in biggest faller status on Thursday as it closes stores in Asia, Europe

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News

My T cells activation levels are on high alert on bla bla bla....

Top Stories

AI stocks: What to expect in 2024-25

Noronex joins forces with South32 to look for copper in Namibia

Andrew Forrest was seemingly possessed by the spirit of hydrogen – now he's cut 700 jobs and canned FFI

Evolution shares up 3% on quarterly results for June showing rise in gold production

Domino's locks in biggest faller status on Thursday as it closes stores in Asia, Europe

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News