“”In some embodiments, `siRNA-mediated gene targeting is...

“”In some embodiments, `siRNA-mediated gene targeting is accomplished through the use of DNA-directed RNA interference (ddRNAI) which is a gene-silencing technique that utilizes DNA constructs to activate an animal cell's endogenous RNA interference (RNAi) pathways. Such DNA constructs are designed to express self-complementary double-stranded RNAs, typically short-hairpin RNAs (shRNA), that once processed bring about silencing of a target gene or genes.””

http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PG01&s1=Ddrnai&OS=Ddrnai&RS=Ddrnai


“”Such as RNAi, antisense and nucleic acid based polymers targeting HBV RNA; e.g., RNAi (for example ALN-HBV, ARC-520, TKM-HBV, ddRNAi), antisense (ISIS-HBV), Well things are heating up. Below are some new applications for use of our proprietary technology ddrnai in the USA. Could these be some of our new collaborations to be announced in the pipeline update.””

http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=2&f=G&l=50&co1=AND&d=PG01&s1=Ddrnai&OS=Ddrnai&RS=Ddrnai