We understand the similarities between NNZ-2566 and NNZ-2591 but it is understanding the differences which will create alternative therapeutic pathways. It appears that NNZ-2591 may have a more direct effect on synaptic signalling.
Neurons do not connect with each other but communicate through a junction called a synapse. The junction is what Professor Mike Snape - http://vimeo.com/71532531 - might call the 'twitter space' where there are glia-neuron interactions, namely microglia and astrocyte.
There is a growing level of excitement about the MOA for NNZ-2591. The US Army is "characterising the impact of the drug on the restoration of synaptic function". Neuren have commenced testing NNZ-2591 in a mouse model of MS which is characterised in part by abnormal functioning of microglia.
Although the reasons are not yet fully understood, it does appear that NNZ-2591 is quite distinct from NNZ-2566. The results from the testing of NNZ-2591 in a mouse model for MS are eagerly anticipated.
biggest competitor to nnz-2566
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