It is sad that inflection points and milestones do not attract massive interest. Heck I remember a few years ago that a biotech company would announce a basic patent was granted in a foreign jurisdiction and the market cap would double. Admittedly that was at the very lower end of the scale, absolute microcaps.
I mentioned on other posts that the sector needs a big winner or two to ignite interest again. A biotech lifecycle imo is not dis-similar to that of a mining explorer. Trials and approvals along the way are a bit like drilling and proving up a resource that may ultimately not be economic/commercial. Risk money will move away from speccy mining stocks and need a home.
I've taken these points from ausbiotech's website which show reasons for investing in biotech and I agree with each:
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
Investment leverage – exciting potential for significant above-average returns;
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
Attractive valuations – relative to the potential top-line and bottom-line growth;
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
Maturing sector profile – more Australian and Asian companies getting closer to commercialisation age;
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
Sector rotation – risk capital seeking returns outside of resources;
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
M & A activity – large pharmaceutical companies are looking to add to their drying pipelines. The average acquisition premium was 66% (with 47% median) based on the last 82 transactions compiled by Citigroup;
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
Qualified talent is being drawn to the biotechnology industry;
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
Demographic drivers – ageing population in the Western world is providing increased momentum and investor flows; and
![](http://www.ausbiotech.org/userfiles/image/Purple_bullet.bmp)
Regulatory pathway improving – the time required to get approval is reducing. A recent example is the ‘Breakthrough’ therapies pathway created by the FDA Safety and Innovation Act.
Immugene released a good presentation today, worth a look. Shows how undervalued they possibly are compared to overseas peers. I don't hold Immugene, but I follow as immugene are one of the companies (alongside Oncosil which you mentioned) which was set up recently by Forrest Capital.
Back to your first point, Pigofsteel, I think investors are worried about losing 80-90% of their capital overnight, which happens and has happened recently. The key IMO is to take a portfolio approach with biotech - rather than try and pick a single winner, spread capital over a small portflio of biotechs. Some won't make it, some will just flounder, whilst one may make it and it is this single stock that will more than make up for any of the others failing. Unless they are all bad!