"Cpn10 reduces intra-renal expression of pro- inflammatory cytokines in MRL(Fas)-lpr mice"
"We speculated that Cpn10 would suppress intra-renal inflammation and therefore nephritis by inhibiting pro- inflammatory signals. Hence, we studied the messenger RNA (mRNA) expression levels of various pro-inflammatory cytokines that have previously been shown to contribute to renal immunopathology in MRL(Fas)-lpr mice. Cpn10 treatment was associated with a significant reduction of intra-renal monocyte chemotactic protein-1 (MCP-1)/che-mokine (C-C motif) ligand 2 (CCL2), IL-6 and TNF-a mRNA expression (Figure 5)"
Notice the words "Significant reduction" and "IL-6" ;)
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