Functional and druggability analysis of the SARS-CoV-2 proteome
https://www.biorxiv.org/content/10.1101/2020.08.21.261404v1.full.pdf
E Protein
It is a small homopentameric membrane protein (75 amino-acids per protomer) [180], which has been shown to be essential for viral particle assembly in SARS-CoV [51]. The N-terminal region of the protein spans the lipid bilayer twice, while the C-terminal is exposed to the interior of the virus [181,182]. In IBV and SARS-CoV, the E protein interacts with the viral M protein through an undefined region [183,184]; and also with the host Protein Associated with Lin Seven 1 (PALS1), a factor associated to the pathogenesis [185], thought the E protein C-terminal. Also, in many CoVs, the E protein works as an ion-channelling viroporin [180], which affects the production of cytokines,
and in consequence the inflammatory response [186]. While there is no structural data available for the SARS-CoV-2 E protein, the structure of the TM region of the SARS-CoV homopentamer is available (residues 8-65) (PDB 5X29). Within that region, e corresponding E proteins share 91% sequence identity, and 98% sequence similarity. The homology model of the SARS-CoV-2 E protein is shown in Figure S12. Based on structural andfunctional considerations, the E protein channel would be the primary target site for drug development. In fact, hexamethylene amiloride (HMA) has been reported to bind to the SARS-CoV E protein homopentamer, but not to an isolated protomer [187].
Its a long paper getting into all aspects of Covid targets, the above is the relevant section that may interest BIT holders.
note : Hexamethylene amiloride (HMA) analogue (BIT225)
- Forums
- ASX - By Stock
- BIT036- a likely candidate for curing COVID-19
Functional and druggability analysis of the SARS-CoV-2...
-
- There are more pages in this discussion • 1,402 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add BIT (ASX) to my watchlist
|
|||||
Last
3.2¢ |
Change
0.000(0.00%) |
Mkt cap ! $28.87M |
Open | High | Low | Value | Volume |
3.3¢ | 3.3¢ | 3.2¢ | $17.40K | 542.8K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
1 | 17000 | 3.1¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
3.3¢ | 120000 | 2 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
1 | 17000 | 0.031 |
8 | 342305 | 0.030 |
5 | 1208888 | 0.029 |
4 | 468000 | 0.028 |
2 | 537000 | 0.027 |
Price($) | Vol. | No. |
---|---|---|
0.033 | 120000 | 2 |
0.034 | 100000 | 1 |
0.035 | 317251 | 4 |
0.036 | 460000 | 2 |
0.037 | 537816 | 2 |
Last trade - 16.10pm 29/07/2024 (20 minute delay) ? |
Featured News
BIT (ASX) Chart |