BIT036- a likely candidate for curing COVID-19, page-669

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Bullrush007

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24/08/20

15:13

Post #: 46772062
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Originally posted by Colingray: ↑

Functional and druggability analysis of the SARS-CoV-2 proteome

https://www.biorxiv.org/content/10.1101/2020.08.21.261404v1.full.pdf

E Protein

It is a small homopentameric membrane protein (75 amino-acids per protomer) [180], which has been shown to be essential for viral particle assembly in SARS-CoV [51]. The N-terminal region of the protein spans the lipid bilayer twice, while the C-terminal is exposed to the interior of the virus [181,182]. In IBV and SARS-CoV, the E protein interacts with the viral M protein through an undefined region [183,184]; and also with the host Protein Associated with Lin Seven 1 (PALS1), a factor associated to the pathogenesis [185], thought the E protein C-terminal. Also, in many CoVs, the E protein works as an ion-channelling viroporin [180], which affects the production of cytokines,
and in consequence the inflammatory response [186]. While there is no structural data available for the SARS-CoV-2 E protein, the structure of the TM region of the SARS-CoV homopentamer is available (residues 8-65) (PDB 5X29). Within that region, e corresponding E proteins share 91% sequence identity, and 98% sequence similarity. The homology model of the SARS-CoV-2 E protein is shown in Figure S12. Based on structural andfunctional considerations, the E protein channel would be the primary target site for drug development. In fact, hexamethylene amiloride (HMA) has been reported to bind to the SARS-CoV E protein homopentamer, but not to an isolated protomer [187].

Its a long paper getting into all aspects of Covid targets, the above is the relevant section that may interest BIT holders.
note : Hexamethylene amiloride (HMA) analogue (BIT225)

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ReframeDB database currently shows no Covid-19 assay hits for BIT225 unfortunately

ReframeDB is comprehensive but hopefully not updated to reflect the successful hits

What happened with BIT225 and HCV..radio silence from BIT

Im in mainly for BIT225 and it’s HIV1 (and HVC if still relevant) prospects

The bump, Pharma financing for Phase 3 but it could be another 4-5 years before any royalties are generated from global sales

BIT Price at posting: 9.8¢ Sentiment: None Disclosure: Held
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BIT036- a likely candidate for curing COVID-19, page-669

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BIT036- a likely candidate for curing COVID-19, page-669

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