It would be interesting to know what the range of readings was amongst the patients over the dose range to understand whether there is a large variation between how drug is metabolised/excreted after dosing (where are the standard deviation/standard error values for all of this data!? I'm assuming what they're reporting are mean values).
Perhaps the previous results were from a smaller number of patients where excretion happened very rapidly, leading to the higher result? Once more patients were recruited and dosed, the variability may have pushed this peak concentration down, giving them the result they reported yesterday. Just speculation - would be good to hear it from the horses mouth.
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