There are a number of things I particularly like about the IONIC trial:
- IONIC is a study involving both NOX and Bristol-Myers Squibb
- Cohort 1 will have recently failed Opdivo – any improvement should be quickly apparent and will be due to Veyonda
- Cohort 2 will be unsuitable for Opdivo – any response will prove that Veyonda can restore the immune function in all tumours
- Veyonda will be used at higher dosages than in earlier trials
- As Veyonda plus Opdivo could threaten the position of Keytruda, I imagine that Merck will closely watch developments
- In an ideal world, BMS and Merck would get into a bidding war.
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