NOW I have stated in prior posts that I SUSPECT that iPPS is not just a regular passive agent/molecule.....We know iPPS...
Reduces inflammation
It increases blood flow via it's mild anti-coagulant properties
It addresses, via down regulation, (importantly it DOESN'T blanket block) NGF.
But in addition to the above...I believe it has a
PROACTIVE role. I'm getting the idea that my speculation has some evidence behind it. The evidence I just recently uncovered is that iPPS acts as a binding agent....yes, here isthe James Bond part...it forms a
Bond. "...experiments were undertaken to isolate and characterize proteins in human AC which have the potential to bind PPS".Furthermore,
"...synovial fibroblasts derived from OA joints were shown to secrete thrombospondin and also bind PPS. "3What does that mean? Well this is what I've been suggesting....iPPS plays a proactive role in this healing process...
Note: AC = Articular cartilageSynovial fibroblasts are those few cell thick membranes of cells within the synovial walls.Who came up with this idea (Above quotes and research)? None other than our own P. Ghosh. Amazing.
So now in Mozzie® Speak. This means that iPPS gets into the synovial joint...it has a PRO ACTIVE role....and Paradigmers we know that the levels of COMP for instance are higher in the joint. Not only that but referring to the heat map we also know there is a lot more cytokines within the joint. What I am possibly implying is that there are more cytokines TO reduce within the synovium as opposed to in the serum. In other words, I suspect the % reduction will be greater taking the sample before and after iPPS from the synovial joint like what will happen in 008 compared to the serum like what occurred in Phase 2B. It's completely my own speculation here, I could be totally wrong...you not only should do your own research, but think about it for yourself.
I do...
Why? Because this means that 008 will have even better results than 2B...this will likely show at least the same OR BETTER reduction in the biomarkers, thus showing that iPPS is great for reducing the biomarkers in the blood but even (maybe only slightly) better reduction within the joint...thus assisting to demonstrate that iPPS has the ability to slow.....halt...and in some cases REVERSE the onset of OA. Certainly we have seen the dramatic and quick reduction of BMLS...with posters from within HC-PAR reporting on their great success.
Not strictly a Bond girl per se...they have even more colourful names than just 'Rose' or 'Lilly'...Dr Christmas for example... then there was that err well Galore girl...
Hmmm no ordinary 'Rose' there was something about Dr Christmas that was unique...that whole steamy but plain Jane look...I love roses...we used to have a beautiful rose garden in a lovely property in a country town in Victoria....the smell of those ...mmmm
What the heck has this to do with us Mozz...please...The amazing connection and comparison with Synovial Fluid, Serum, iPPS and a rose....iPPS is not a passive molecule...it binds.....it actually links and directly interacts via a
rosetting process (think floral look a like arrangement , a scientifically cute way of saying clustering)...A quote from the same Ghosh reference:
"Using bovine erythrocytes conjugated with PPS a rosetting of the synovial fibroblast could be demonstrated".Dr P Ghosh certainly knew about the active role the iPPS complex molecule takes....more research is just around the corner...the world will know about us and in how many years?
An example of cells rosetting.4
Further evidence can be found in another study to do with an equine study.The reason for this study
5 was to observe PPS's effect in donkeys.The results and the conclusion summarise it in full and were published in the Journal of Arthritis back in 2016:
Results: Induction of osteoarthritis caused increase in the lameness score, joint circumference, synovial fluid calcium, phosphorus, magnesium, total protein and leukocyte count and cartilage damage. NaPPS treatment significantly reduced synovial fluid Ca, Mg, P and cartilage damage.
Conclusions: NaPPS resulted in significant improvement in clinical signs and articular cartilage healing, and no adverse effects were detected confirming that NaPPS has disease-modifying properties As a secondary proof, a study in hamsters resulted in the following observation
"The pharmacokinetics of PPS is unusual, in part because it is a pharmaceutical product with a range of medium-molecular-weight compounds, and in part because these tightly bind serum proteins and proteoglycans on cell surfaces and connective tissue." 6So we have the two parts now...we have the science behind us...and we have the empirical evidence as articulated by posters on here at HC. Par-Peoples...this is the proof we need...as I say, we are early to this party...all you gotta do is wait and be patient.
Not unlike the next Bond film, I anticipate our own marvellous productions. Paradigmers, this won't be a production to be released only locally...we will hit screens everywhere in the world and a lot of it will be simultaneously.This journey would have been much longer if we were doing USA and Europe in tandem....yes it's not going to be tomorrow or the next month, we might have to wait a couple of years for the real release of this iPPS-OA film...but certainly there are real prospects of deals being done much before the official registration occurs.
Paradigmers, as I have said before and is worth repeating here...the safe reduction of pain to thresholds that are BETTER than opioids is ONE thing....showing that we have any scope of DMOAD is quite another. We are embarking on a WORLD first journey to prove this...we make it through this exam with even a pass...the world will pay up BIG time and in numbers that even we cannot imagine. When I read up on the actual MOA...I read from scientific INDEPENDENT publications and reports.....I think of another James.... Labron James.
This is an athlete that is just so good at his game...he is committed he is focused...he trains.....and he trains...3 sessions every day at the gym...in the off season? He still wakes up at 5am...and trains...shooting hoops is so second nature to him...he goes into a mode...he has had the same coach since his College days.
What are the chances this guy will make this shot? What are the chances WE will make P3 successful readout and become a global sensation like him?Paradigmers, this is a guy that has conditioned himself to make basket scoring second nature to him. What then are the chances of him making any given shot? I'm also not at all saying that there will never be competition to us and that it will work for 100% of folks, we have had unfortunate examples right here at HC where there is evidence of almost no pain relief....we do not know all the circumstances, it will come out in more longitudinal type studies...Sure Labron might make a miss step or hit the rim on the odd shot....but the majority? They go in.
It's the same game for us...yes I'm not saying we don't have the odd shot that won't go in...the odd error, the odd mis step...but man....look at the data...look at the science...look at what works...look at the percentage iPPS gets in the ring....it's going to be one heck of a game when it starts...not unlike the anticipation of the latest Bond film to go back to that analogy for sec ......we're early in the stadium or at the movies, I can't see many spectators/patrons yet....but give it time...they will come and who will be in the best seat to view this spectacle?
You and I.
DYOR as always.
1) https://www.sciencedirect.com/science/article/abs/pii/S0973369810605560#:~:text=COMP%20levels%20were%20higher%20in,thickness%20(P%20%3C0.001).
2)
https://creakyjoints.org/education/what-is-synovitis/3)
https://pubmed.ncbi.nlm.nih.gov/8731395/4)
https://dev.biologists.org/content/141/13/25495)
https://irp-cdn.multiscreensite.com/d048e3f1/files/uploaded/JT%20-%20Pentosan-polysulfate-as-a-disease-modifier.pdf6) Simon Mead, Fabrizio Tagliavini, in Handbook of Clinical Neurology, 2018
(20min delay)