brain cancer & the blood brain-barrier, page-13

"Mark Dennis, from Genentech's department of antibody engineering, who took advantage of the fact that all cells, including brain cells, need iron. He engineered an antibody with two arms. One arm was the anti-BACE1 drug; the other docked with a receptor called transferrin that carries iron to brain cells, providing a ferry across the barrier.




you do know in humans Transferrin is a polypeptide :-):-)

that sounds like a pretty large antibody which fits bang on with the intial Roche partnership objectives of "transporting large molecules to attack disease targets within cells"

also the last Phylomer listed on page 35 of this weeks presentation..

We will soon see......