I spoke to Troy about AD109, MB has had a thorough look at...

I spoke to Troy about AD109, MB has had a thorough look at it.

Patients treated with it got less REM sleep.

All well and good to have good read outs within the trial, but people cannot live a healthy life without proper REM sleep.

In there next trial people go 6-12 months with reduced REM sleep, their phase two trial, albeit a big one, went for just one month.

This is straight from Google.

Evidence suggests that it is an essential physiological phenomenon to the extent that prolonged REM sleep deprivation may be fatal. REM deprivation increases basal arousal and enhances drive-related behaviors like hyperphagia. It also affects physiological, psychological process as well as neurotransmitter levels.

These guys are using atomoxetine in their drug, it is used for ADHD.
Atomoxetine and reboxetine (in Europe) are selective adrenergic reuptake inhibitors. Both compounds were developed as antidepressants, but atomoxetine is now mainly used in the therapy of ADHD. Although these compounds are not stimulants per se, they are slightly wake promoting59,60 and reduce REM sleep.