Can Monepantel help cure HIV ?, page-9

First 9 Last

Share
Profile

Follow
Jockthegreat

2,773 Posts.

1518

24/02/21

17:49

Post #: 51293949
Share

Originally posted by kpax: ↑

Hi Jockthegreat,

Your question is basically what’s the difference between MPL and other mTOR inhibitors , and why have the others not achieved their intended goals ?

There is now four generations of mTOR inhibitors. Rapamycin approved by the FDA the first in 1997.
It only inhibits mTOR activity, it didn’t bind with the kinase ( cell signalling in the Cancer cell).

The second generation was called Rapalogs, they were formed by replacing the hydrogen element in the Rapamycin molecule. They had better solubility and a smaller molecules, they were called Temsirolimus/Everolimus and Ridaforalimus. Efficacy in Cancer was improved marginally. They were authorised by the FDA in 2007. But, the only target seemingly for these rapalogs was renal cell carcinoma and mantle cell lymphoma. Rapalogs also didn’t cause cancer cell death. What was found that prolonged drug administration caused a negative feedback loop that resulted in promoting the P13K/ AKT( cellular replication pathway) activity which actually helped the cancer cells proliferate.

Does MPL have the same activity, the answer is No.

Along came a third generation of mTOR inhibitors that possessed inhibitory P13K/AKT activity, but are they selective enough to combat the many types of cancer. The answer is No. They still don’t “kill” the cancer cell, at best they suppress it.

Out of chance, a very smart chap called Dr Roger Aston found that not only does MPL inhibits the P13K/AKT pathway but, in addition MPL arrests the cell cycle of the cancer. It killed the cancer. He decided to explain why, under a microscope, Roger found that the cancer cells had a loss of plasma integrity. Thus allowing our bodies immune response via our killer T cells to clear other cancer cells. Generation four had begun.
So that’s it, Monepantel works in Cancer differently in MND as well as Covid 19.

Jock, your next question may be who else has our knowledge. There is three competitors MLN0128 as well as PP242 then AZD2014. Do they work yes, do they have a more limited range of targets, yes.
They are all in Phase 2 studies to my knowledge.

We have the edge.

Expand

Thanks for taking the time kpax, really interesting and exciting potential.

PAA Price at posting: 10.0¢ Sentiment: Hold Disclosure: Held
8 Upvote

0 Great analysis

Reply

Top Stories

IRX

InhaleRX gains approval for clinical trial to test non-opioid therapy for cancer pain

GDM

Banshee's historic trenches prove rich in antimony and gold for GDM

3DA

To make modern missiles, you need 3D Printing. And in that gold rush, Amaero is selling shovels

BNL

Blue Star Helium sees approval for five more wells at 'Galactica/Pegasus' project in Colorado

BTH

Bigtincan's Board backs Investcorp offer: Why a NASDAQ listing could be game-changing

First 9 Last

Add NUZ (ASX) to my watchlist

(20min delay)
Last 20.0¢		Change 0.010(5.26%)		Mkt cap ! $98.34M

Open	High	Low	Value	Volume
20.0¢	20.5¢	19.5¢	$60.93K	303.3K

Buyers (Bids)

No.	Vol.	Price($)
2	49269	19.5¢

Sellers (Offers)

Price($)	Vol.	No.
20.0¢	87005	2

View Market Depth

No.	Vol.	Price($)
2	49269	0.195
6	254668	0.190
11	723500	0.185
7	383274	0.180
5	151797	0.175

Price($)	Vol.	No.
0.200	87005	2
0.205	126605	4
0.210	107679	3
0.215	154400	2
0.220	140000	2

Last trade - 13.14pm 15/11/2024 (20 minute delay)

NUZ (ASX) Chart

Can Monepantel help cure HIV ?, page-9

InhaleRX gains approval for clinical trial to test non-opioid therapy for cancer pain

Banshee's historic trenches prove rich in antimony and gold for GDM

To make modern missiles, you need 3D Printing. And in that gold rush, Amaero is selling shovels

Blue Star Helium sees approval for five more wells at 'Galactica/Pegasus' project in Colorado

Bigtincan's Board backs Investcorp offer: Why a NASDAQ listing could be game-changing

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News

Can Monepantel help cure HIV ?, page-9

Top Stories

InhaleRX gains approval for clinical trial to test non-opioid therapy for cancer pain

Banshee's historic trenches prove rich in antimony and gold for GDM

To make modern missiles, you need 3D Printing. And in that gold rush, Amaero is selling shovels

Blue Star Helium sees approval for five more wells at 'Galactica/Pegasus' project in Colorado

Bigtincan's Board backs Investcorp offer: Why a NASDAQ listing could be game-changing

Featured News

Buyers (Bids)

Sellers (Offers)

Featured News