Inhibition of CDK7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy
https://pubmed.ncbi.nlm.nih.gov/38646672/
Conclusions: Activation of CDK7 is necessary for DOX-induced cardiomyocyte apoptosis and cardiomyopathy. Our findings uncover a novel proapoptotic role for CDK7 in cardiomyocytes. Moreover, this study suggests that inhibition of CDK7 attenuates DOX-induced cardiotoxicity, but augments the anticancer efficacy of DOX. Therefore, combined administration of CDK7 inhibitor and DOX may exhibit diminished cardiotoxicity but superior anticancer activity.
Inhibition of CDK7 mitigates doxorubicin cardiotoxicity and...
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