That's true. The FDA approved dosage is 52 mg/m2 in paediatrics and 40mg/m2 in adults. Sheba 2.0 dosage was 30 mg/m2.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021673s024lbl.pdf
https://pubmed.ncbi.nlm.nih.gov/19260120/
The cardiotoxic profile of Clofarabine is (IMO) under appreciated due to the lack of data (and the lack of willingness to even report it!).
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That's true. The FDA approved dosage is 52 mg/m2 in paediatrics...
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