I have created this chart to visually represent the universal role Bisantrene plays in cardioprotection against common cardiotoxic chemotherapies. A 1 uM dose of Bisantrene significantly improves HCM viability (p < 0.001). The real value for this opportunity is that while providing cardioprotection, Bisantrene improves cancer cell killing in combination with these chemotherapies. There are already 2 clinical trials where Bisantrene is used in combination with moderately cardiotoxic chemotherapies not listed in the figure below that achieved combined ORR of 46% and 40% with no clinically relevant signs of cardiotoxicity.
A drug with a universal cardioprotection mechanism combined with a universal cytotoxicity mechanism has not existed until now.
Cardioprotection thread, page-518
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Last
$1.79 |
Change
-0.075(4.02%) |
Mkt cap ! $304.8M | |||
| Open | High | Low | Value | Volume |
| $1.86 | $1.86 | $1.76 | $348.2K | 192.6K |
Buyers (Bids)
| No. | Vol. | Price($) |
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| 1 | 5612 | $1.77 |
Sellers (Offers)
| Price($) | Vol. | No. |
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| $1.79 | 3567 | 1 |
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| Last trade - 16.10pm 14/06/2024 (20 minute delay) ? |
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Last
$1.78 |
Change
-0.075 ( 5.38 %) |
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| Open | High | Low | Volume | ||
| $1.81 | $1.86 | $1.76 | 27553 | ||
| Last updated 15.55pm 14/06/2024 ? | |||||
| RAC (ASX) Chart |