interesting stuff, seems to be protective using receptor and anti cancer RAS inhibitor mechanism.
No expert but although a currently approved product it’s for blood pressure control, to be used for cancer and in combo with dox would require trials, so being first to market is relevant. Off-label use wouldn’t be a feasible strategy.
RAS inhibitor may be selective and promising anti-cancer in certain cancer indications, you can see the two groups below one performing well and group B (perhaps not impacted by RAS) which was underwhelming anti-cancer and x100 dose of Bisantrene.
Included Bisantrene as a comparative, note the IC50
dosing.
http://dx.doi.org/10.1177/1470320319851310
Cardioprotection thread, page-687
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