I am wondering if the 7 day lead in dosage of bisantrene planned for the P2 trial will not only act as a way to gather data on FTO inhibition, but will also increase the chances of seeing a cardio protective effect.
The reasoning is that there are multiple MOAs for doxorubicin as an anticancer agent (one reason why it's particularly effective) and there are multiple MOAs for it's cardiotoxicity. Therefore if bisantrene is cardio protective, it will have to somehow stop doxorubicin from getting into heart cells and doing it's damage. If administered by itself first, could bisantrene "saturate" heart cells and prevent the doxorubicin damage?
Interested to hear your thoughts.
Happy New Year everyone.
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