That's true. The FDA approved dosage is 52 mg/m2 in paediatrics and 40mg/m2 in adults. Sheba 2.0 dosage was 30 mg/m2.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021673s024lbl.pdf
https://pubmed.ncbi.nlm.nih.gov/19260120/
The cardiotoxic profile of Clofarabine is (IMO) under appreciated due to the lack of data (and the lack of willingness to even report it!).
That's true. The FDA approved dosage is 52 mg/m2 in paediatrics...
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