Benzoyl peroxide and tetrinoin, no much of a disruption...

Benzoyl peroxide and tetrinoin, no much of a disruption there.
Apart from being readily standardised and available substances (unlike cannabidiol) with a known safety profile, the data is actually not that great with differences in lesion count between active and placebo in the single digits across all arms:

In trial SGT-65-04, the absolute change from baseline of inflammatory lesion count for Twyneo was -21.6 versus -14.8 for the vehicle group (P<0.001). In trial SGT-65-05, the absolute change from baseline of inflammatory lesion count for Twyneo was -16.2 versus -14.1 for the vehicle group (P=0.021).

In trial SGT-65-04, the absolute change from baseline of non-inflammatory lesion count for Twyneo was -29.7 versus -19.8 for the vehicle group (P<0.001). In trial SGT-65-05, the absolute change from baseline of non-inflammatory lesion count for Twyneo was -24.2 versus -17.4 for the vehicle group (P<0.001).