Title:MOBILIZING LEUKEMIA CELLSUnited States Patent Application...

Title:MOBILIZING LEUKEMIA CELLSUnited States Patent Application 20180355360Kind Code:


A1A method for mobilizing leukemia cells which are α4 integrin positive to the peripheral blood of a human subject, the method comprising administering to the human subject an effective amount of an antisense compound to α4 integrin. The cells may be mobilized from bone marrow. The antisense compound is: 5′-MeCMeUG AGT MeCTG TTT MeUMeCMeC AMeUMeU MeCMeU-3′ wherein, (a) each of the 19 internucleotide linkages of the oligonucleotide is an O,O-linked phosphorothioate diester; (b) the nucleotides at the positions 1 to 3 from the 5′ end are 2′-O-(2-methoxyethyl) modified ribonucleosides; (c) the nucleotides at the positions 4 to 12 from the 5′ end are 2′-deoxyribonucleosides; (d) the nucleotides at the positions 13 to 20 from the 5′ end are 2′-O-(2-methoxyethyl) modified ribonucleosides; and (e) all cytosines are 5-methylcytosines (MeC), or a pharmaceutically acceptable salt thereof

.Inventors:Tachas, George (Kew, AU) Kim, Yong-mi (Los Angeles, CA, US) Application Number:15/971938Publication Date:12/13/2018Filing Date:05/04/2018Export Citation:Click for automatic bibliography generationAssignee:Antisense Therapeutics Ltd (Toorak, AU) Children's Hospital of Los Angeles (Los Angeles, CA, US) International Classes:C12N15/113; A61K31/7076; A61P35/02View Patent Imagesownload PDF 20180355360 PDF help


George:: Already been done by Anp