Cell Therapy News/Articles, page-18278

was being selective .... if this is true what pointer will MSB use to confirm endpionts
"There is no association between pain and MRI appearance"

they seemed to cut back or discard a large number of acceptable output and then these complications. still my back issue fit in well with the aim and would have it tomorrow.

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MSCs can differentiate into fibroblasts⁵⁹ and strengthen the annulus, preventing herniation by depositing new collagen fibres. In fact, 85% of patients showed a reduction in posterior bulge. A reduction of at least 25% of the bulge decreased the pain significantly. Only one case of herniation that required surgery was reported after 5 months. This complication could have resulted from needle injection, excessive proliferation of MSCs or excessive production of ECM.

Among the complications related to the injection of MSCs is the formation of osteophytes in the tissues surrounding the injection site.⁷⁹

When conservative therapy failed, it is possible to use different surgical methods,^7,80 but these have several complications: dural lesions, infections and epidural hematomas.^81–84 In stabilization of the spine, for example, by limiting the movements of the affected section of the spine, the stress imposed to the adjacent vertebrae is increased, contributing to the degeneration of those discs. Pettine et al. reported about the reduced length of hospital stay with MSC compared with surgical treatment, which involves 5 days in hospital.⁶¹ Despite this, some failure necessitated surgical treatment; for example, three patients were treated surgically between 6 and 12 months after implantation of MSC for persistent pain.⁵²

New therapeutic approaches aim to induce the migration of MSCs to the damaged site and warrant further exploration.^85,86

The limitations of this study are related to the low number of articles, the lack of data on patients, the aetiology of discogenic back pain, the type of culture medium and the solution injected, and the use of different clinical scores in the various studies. All these do not allow to obtain homogeneous results regarding treatment efficacy."