Cell Therapy News/Articles, page-1998

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694112/

But note, now claiming post hoc analysis

Also not clear how long the patients had had COPD. Fibrotic lung damage that has consolidated and scarred has not been much amenable to treatment AFAIK. Much better to prevent or treat early...


On a side note https://www.sciencedaily.com/releases/2018/07/180703131423.htm

Metformin reverses established lung fibrosis

Diabetes drug a potential therapy for idiopathic pulmonary fibrosis, suggests research with human lung fibroblasts, mouse model of lung fibrosis

Date: July 3, 2018

Source: University of Alabama at Birmingham

Summary:

Researchers have shown -- for the first time -- that established lung fibrosis can be reversed using a drug treatment that targets cell metabolism. The finding is important because, despite significant advances to reveal the pathological mechanisms of persistent fibrosis, effective treatment interventions are lacking.

...
Using a mouse model for lung fibrosis elicited by the anti-cancer drug bleomycin, the research team found metformin treatment, starting three weeks after lung injury and continuing for five weeks, accelerated the resolution of well-established fibrosis. Such resolution was not apparent in AMPK-knockout mice, showing that the effect of metformin was AMPK-dependent.
...