New study in autopsies of patients who died from Covid-19, proves that in damaged tissues the concentration of Covid-19 virus is actually low but that tissue damage is caused by the dysregulation of the immune system.
https://www.medrxiv.org/content/10.1101/2020.07.02.20145003v1.full.pdf+html
Conclusion:
Taken together, the present data provide comprehensive clinical, viral and inflammatory
profiling of fatal Covid-19. These highlight, for the first time, the discrepancy between the
presence of SARS-CoV-2 and tissue inflammation. Given the recent discovery that
immunosuppression with dexamethasone prevents death in severe Covid-19, our
observations support virus-independent immunopathology being one of the primary
mechanisms underlying fatal Covid-19. This suggests that better understanding of noninjurious, organ specific viral tolerance mechanisms and targeting of the dysregulated immune response merits further investigation within the broader context of management of Covid-19.
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