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    https://www.futuremedicine.com/doi/10.2217/bmm-2020-0683



    Biomarkers in Medicine
    Vol. 15, No. 10Special Report
    Open Access

    Screening for regenerative therapy responders in heart failure

    Satsuki Yamada, Ryounghoon Jeon, Armin Garmany, Atta Behfar & Andre Terzic

    Published Online: 25 Jun 2021

    https://doi.org/10.2217/bmm-2020-0683


    Abstract

    Risk of outcome variability challenges therapeutic innovation. Selection of the most suitable candidates is predicated on reliable response indicators. Especially for emergent regenerative biotherapies, determinants separating success from failure in achieving disease rescue remain largely unknown. Accordingly, (pre)clinical development programs have placed increased emphasis on the multi-dimensional decoding of repair capacity and disease resolution, attributes defining responsiveness. To attain regenerative goals for each individual, phenotype-based patient selection is poised for an upgrade guided by new insights into disease biology, translated into refined surveillance of response regulators and deep learning-amplified clinical decision support.


 
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