So they have those receptors on these cells that detect the...

So they have those receptors on these cells that detect the environment they’re in, and if they see, for example, they’re in the middle of a tissue that has a lot of inflammation, will they immediately send out signals and proteins and different things to affect and change that inflammation. And we think that that is what is really helping in the clinical trial, when we put these cells in an inflamed heart, and we see that most of the benefit is in the patients that have inflammation, that they can turn that around.“

Dr. Emerson Perin:
Yeah, that’s true, we treated the first, you know, human with heart failure with stem cells back in 2001, in Brazil. And at that time, we were using a fairly simple product, which is sort of filtered bone marrow cells called autologous bone marrow mononuclear cells. And over the years, we have attempted using different cells, some specifically selected from different tissues. And we’ve learned a lot.

And we’ve kind of come from an initial, more naive notion that we just kind of threw the cells at the problem, and maybe some magic happen, to a much better understanding of the mechanisms at play, and I would say that today, the best cell that we have against—to treat heart failure is an anti-inflammatory cell, and that the mesenchymal cells are fantastically anti-inflammatory, and, very importantly, they can read their environment.

Above interview with Dr. Emerson Perin, lead investigator of the DREAM-HF trial, happened in 2022.Keep reading, it is very interesting.

https://myheart.net/articles/stem-cells-in-heart-failure-with-dr-emerson-perin/

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