Verapamil blocks calcium channels by binding to specific...

Verapamil blocks calcium channels by binding to specific receptors on the L-type calcium channels in cardiac and smooth muscle cells. This binding inhibits the influx of calcium ions through these channels, thereby reducing the intracellular concentration of calcium. By blocking calcium influx, verapamil prevents smooth muscle contraction and dilates coronary and systemic arteries, leading to decreased blood pressure and reduced myocardial oxygen demand.

Verapamil hydrochloride, commonly known as verapamil HCl, is the salt form of verapamil. In this form, the verapamil molecule is combined with hydrochloride (HCl) ions. The addition of the hydrochloride salt increases the water solubility of verapamil, enhancing its absorption and bioavailability in the body. This allows for more consistent and reliable delivery of the drug to its target sites, potentially improving its effectiveness in blocking calcium channels.

Bisantrene has 2 parts HCI