@Beaza79
"Can u in laymen’s terms try to explain how on earth u change the properties of a drug?? I can’t get my head around how this is possibly done."
I was interested also so asked ChatGPT
Changing the properties of a drug involves modifying its chemical structure to alter how it behaves in the body. Here’s a simplified explanation of how scientists do this:
Understand the Drug’s Structure and Function:
- Every drug is made up of molecules, which are groups of atoms bonded together in specific ways.
- Scientists study the drug’s molecular structure to understand how it works in the body. They look at which parts of the molecule interact with the body to produce the desired effect (like relieving pain) and which parts might cause unwanted side effects.
- Scientists use their knowledge of chemistry to make small changes to the drug’s molecule. This can involve adding, removing, or replacing specific atoms or groups of atoms within the molecule.
- For example, they might add a new chemical group to the molecule to help it dissolve better in water, making it easier for the body to absorb.
- After making modifications, scientists test the new version of the drug to see how the changes affect its properties.
- They look at things like how well it binds to its target, how long it stays active in the body, how it's absorbed, distributed, metabolized, and excreted, and what side effects it causes.
- This process of modification and testing is repeated many times. Each cycle helps scientists better understand which changes improve the drug and which don’t.
- The goal is to find a version of the drug that is more effective, has fewer side effects, or has other improved properties (like a longer shelf life or better stability).
- Advanced tools like computer modeling and simulations help predict how changes to the drug’s structure might impact its behavior.
- Laboratory techniques like X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy help visualize the drug’s interaction with its target at a molecular level.
@Beaza79"Can u in laymen’s terms try to explain how on earth u...
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